Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lung Capacity01:47

Lung Capacity

56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Pleura of the Lungs01:13

Pleura of the Lungs

7.7K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
7.7K
Primary Active Transport01:47

Primary Active Transport

200.9K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
200.9K
Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

498
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
498
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

60.7K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of donor-derived cell-free DNA testing after lung transplantation in the precision medicine era.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Integrating data across oscillatory power bands predicts the seizure onset zone in focal epilepsies.

Brain communications·2026
Same author

Clinical features associated with chronic lung allograft dysfunction progression in a multicenter cohort.

American journal of respiratory and critical care medicine·2026
Same author

Airway molecular signatures in antibody-mediated lung transplant rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Considerations for Endpoints in Lung Transplant Clinical Trials: Perspective on the ISHLT Consensus Statement.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Prolonged Invasive Mechanical Ventilation is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction: A Lung Transplant Outcomes Group Study.

Clinical transplantation·2026

Related Experiment Video

Updated: Feb 12, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

759

Primary Graft Dysfunction (PGD) Following Lung Transplantation.

Rupal J Shah1, Joshua M Diamond2

  • 1Division of Pulmonary, Allergy, and Critical Care, University of California, San Francisco, California.

Seminars in Respiratory and Critical Care Medicine
|March 29, 2018
PubMed
Summary

Primary graft dysfunction (PGD) after lung transplant is a major cause of death. Research focuses on improving PGD definition, risk factors, and therapies to enhance patient survival and quality of life.

More Related Videos

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

21.1K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.9K

Related Experiment Videos

Last Updated: Feb 12, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

759
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

21.1K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.9K

Area of Science:

  • Pulmonology
  • Transplant Surgery
  • Critical Care Medicine

Background:

  • Primary graft dysfunction (PGD) is acute lung injury following lung transplantation, primarily caused by ischemia reperfusion injury (IRI).
  • PGD significantly contributes to early posttransplant morbidity and mortality, impacting long-term survival and quality of life.
  • Survivors face risks of chronic lung allograft dysfunction, such as bronchiolitis obliterans syndrome, and increased mortality.

Purpose of the Study:

  • To review updated consensus statements on PGD definition, risk factors, mechanisms, and therapeutics.
  • To discuss ongoing challenges and future directions in PGD management and research.
  • To highlight the need for improved PGD predictive algorithms and targeted therapies.

Main Methods:

  • Review of 2017 International Society for Heart and Lung Transplantation consensus statements.
  • Analysis of current PGD risk factors and predictive algorithms.
  • Discussion of controversies and technological advancements in PGD assessment and treatment.

Main Results:

  • Updated PGD definitions and risk factors have been established.
  • PGD predictive algorithms exist but have limited clinical utility.
  • Areas for refinement include grading schemes, outcome measures, and biochemical risk factor incorporation.

Conclusions:

  • Further research is needed to refine PGD grading and predictive models.
  • Development of novel therapies targeting PGD is crucial for improving outcomes.
  • Addressing ongoing controversies will enhance clinical management and trial design for PGD.