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Systemic inflammatory response in a liver transplant recipient: a potential side effect of mycophenolate mofetil

Rebecca Smith1, Adam Testro1,2

  • 1Liver Transplant Unit Victoria, Austin Health, Australia.

BMJ Case Reports
|March 30, 2018
PubMed

Insights

Mycophenolate mofetil can cause rare inflammatory responses and weight loss in liver transplant patients. Stopping the medication led to significant recovery, highlighting a potential adverse effect.

Area of Science:

  • Immunology
  • Pharmacology
  • Gastroenterology

Background:

  • Mycophenolate mofetil is a key immunosuppressant post-liver transplant.
  • Gastrointestinal side effects are common, but rare adverse events are emerging.
  • Monitoring for atypical drug toxicity is crucial in transplant recipients.

Observation:

  • A liver transplant patient developed severe inflammation and weight loss.
  • Symptoms correlated with dose escalation of mycophenolate mofetil.
  • Exhaustive investigations ruled out infection, malignancy, and other inflammatory causes.

Findings:

  • Cessation of mycophenolate mofetil resulted in rapid improvement of inflammatory markers.
  • The patient experienced significant weight regain after discontinuing the medication.
  • This suggests a direct link between mycophenolate mofetil and the observed inflammatory response.

Implications:

  • Highlights a rare, severe adverse effect of mycophenolate mofetil.
  • Suggests the need for heightened awareness and monitoring for inflammatory syndromes.
  • Informs clinical practice regarding the management of potential drug-induced toxicity in transplant patients.
Keywords:
gastrointestinal systemtransplantation

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