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A method for estimating the potency of angiotensin-converting enzyme inhibitors in man
A Wellstein1, J Essig, G G Belz
1Institut für Kardiovaskuläre Therapie, Wiesbaden, Federal Republic of Germany.
British Journal of Clinical Pharmacology
|September 1, 1987
Abstract:
Dose-response curves of the effect of angiotensin I (A-I) infusion on diastolic blood pressure were constructed before and 3 h following single oral doses of the angiotensin-converting enzyme (ACE) inhibitor cilazapril (1.25 to 30 mg) in six normal male subjects. Cilazapril shifted the A-I dose-response curves dose dependently rightward; Schild-plot analysis indicated a competitive antagonism by cilazapril with an apparent Ki-dose of about 0.6 mg.