Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

696
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
696
Transcription Elongation Factors02:35

Transcription Elongation Factors

14.1K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.1K
Transcription Elongation Factors02:35

Transcription Elongation Factors

4.8K
4.8K
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

329
A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
329
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

467
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
467
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

568
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
568

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial.

JAMA cardiology·2026
Same author

Cost-effectiveness of catheter ablation in end-stage heart failure with atrial fibrillation: Insights from CASTLE-HTx.

Heart rhythm·2026
Same author

The year in cardiovascular medicine 2025: the top 10 papers in arrhythmias.

European heart journal·2026
Same author

Association between atherosclerosis and atrial fibrillation progression in patients with paroxysmal atrial fibrillation: Data from the RACE V study.

American heart journal·2026
Same author

Immediate vs Delayed Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: 5-Year Outcomes From the COACT Randomized Trial.

Journal of the American College of Cardiology·2026
Same author

Rethinking Aortic Risk: The Potential Impact of Novel, Adjusted, and Combined Aortic Measures in the Prediction of Aortic Dissection.

The Canadian journal of cardiology·2026

Related Experiment Video

Updated: Feb 12, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K

Aortic elongation part I: the normal aortic ageing process.

Bouke P Adriaans1,2,3, Samuel Heuts3,4, Suzanne Gerretsen1

  • 1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

Heart (British Cardiac Society)
|March 30, 2018
PubMed
Summary

Normal aortic aging involves gradual lengthening and shape changes. The thoracic aorta elongates significantly with age, particularly the descending segment, altering its geometry.

Keywords:
aortic agingaortic elongationvascular aging

More Related Videos

Aortic Ring Assay
09:12

Aortic Ring Assay

Published on: November 24, 2009

32.2K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.7K

Related Experiment Videos

Last Updated: Feb 12, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K
Aortic Ring Assay
09:12

Aortic Ring Assay

Published on: November 24, 2009

32.2K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.7K

Area of Science:

  • Cardiovascular research
  • Vascular biology
  • Medical imaging

Background:

  • Differentiating normal from abnormal vascular aging is vital for predicting adverse outcomes.
  • Normal aortic aging involves gradual dilatation and reduced compliance.
  • The impact of age on longitudinal aortic dimensions and geometry is not well understood.

Purpose of the Study:

  • To describe the normal age-related changes in thoracic aortic length and shape.
  • To investigate the evolution of aortic dimensions throughout the lifespan.

Main Methods:

  • Prospective, cross-sectional study of 210 patients.
  • Utilized third-generation dual-source CT scanner.
  • Performed morphometric measurements on 3D models of the thoracic aorta, including length and tortuosity.

Main Results:

  • Thoracic aorta length significantly correlated with age (r=0.54).
  • Aortic length increased by 59 mm (males) and 66 mm (females) between ages 20-80.
  • The proximal descending aorta showed a 2.5-fold length increase; aortic geometry shifted distally in the elderly.

Conclusions:

  • Normal aging is characterized by aortic elongation and geometric changes.
  • These findings provide a baseline for understanding pathological aortic changes.
  • Further research will explore if excessive elongation contributes to acute aortic dissection.