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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Related Experiment Video

Updated: Feb 12, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Entering the post-epigenomic age: back to epigenetics.

Sebastian Bultmann1, Stefan H Stricker2,3

  • 1Human Biology and BioImaging, Department of Biology II, Ludwig-Maximilian-Universität, BioMedical Center, Grosshaderner Strasse 2, Planegg-Martinsried 82152, Germany bultmann@biologie.uni-muenchen.de.

Open Biology
|March 30, 2018
PubMed
Summary

All cells contain complete genetic information, with differences arising epigenetically. Epigenome editing in epigenome-wide association studies (EWAS) can clarify the roles of epigenomic features in development and disease.

Keywords:
CRISPRCas9dCas9epigenome editingepigenome-wide association studiesepigenomics

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Area of Science:

  • Genetics and Epigenetics
  • Molecular Biology

Background:

  • All cells in an individual contain the same genetic information, implying cellular phenotypes are epigenetic.
  • Transcriptional mechanisms are crucial for cell identity, but molecular control and causal epigenomic features remain unclear.

Purpose of the Study:

  • To highlight the need for understanding molecular control of transcription and the causal roles of epigenomic features.
  • To advocate for the use of epigenome editing technology in epigenome-wide association studies (EWAS).

Main Methods:

  • Discusses the potential application of epigenome editing in conjunction with epigenome-wide association studies (EWAS).

Main Results:

  • Epigenome editing can provide causal insights into epigenomic features.
  • This approach can identify specific genomic locations and conditions critical for development and disease.

Conclusions:

  • Integrating epigenome editing with EWAS is essential for a comprehensive understanding of epigenomic regulation.
  • This methodology will enable researchers to determine which epigenomic features are critical for development and disease states.