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Modafinil Dependence: A Case with Attention-Deficit/Hyperactivity Disorder

Huseyin Alacam1, Omer Basay2, Selim Tumkaya1

  • 1Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Psychiatry Investigation
|March 30, 2018
PubMed

Insights

Attention deficit/hyperactivity disorder (ADHD) patients may develop Modafinil addiction, even though it

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Modafinil is commonly perceived as having a low addiction potential.
  • Limited case reports suggest Modafinil may cause addiction in some individuals.
  • Modafinil is prescribed for attention deficit/hyperactivity disorder (ADHD) symptoms.

Purpose of the Study:

  • To present a case of Modafinil addiction in an adult with ADHD.
  • To highlight the potential for high-dose Modafinil misuse and dependence.

Main Methods:

  • Case report of a patient presenting to a psychiatry outpatient clinic.
  • Detailed description of patient's Modafinil consumption, dosage escalation, and withdrawal symptoms.

Main Results:

  • The patient exhibited Modafinil dependence, requiring 5,000 mg/day.
  • Symptoms included tolerance, withdrawal (irritability, anxiety, sleep disturbances, fatigue, vivid dreams), and drug-seeking behavior.
  • Self-escalation of dosage was driven by the need to maintain therapeutic effects on attention.

Conclusions:

  • ADHD patients are at risk of developing Modafinil addiction.
  • Clinicians should be aware of this potential adverse effect.
  • Further systematic research is needed to understand and address Modafinil addiction in ADHD populations.
Keywords:
Attention-deficit/hyperactivity disorderDependenceModafinil

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