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Updated: Feb 12, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
In vitro cytotoxicity of GO-DOx on FaDu squamous carcinoma cell lines
Manjri Singh1, Parul Gupta2, Richa Baronia1
1CSIR-National Physical Laboratory, New Delhi.
Abstract:
We have synthesized graphene oxide (GO) nanosheets using modified Hummer's method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO-DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO-DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO-DOx drug conjugate for head and neck cancer.
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