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Updated: Feb 12, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

7.1K

Functional miRNAs in breast cancer drug resistance

Weizi Hu1,2,3, Chunli Tan1,2,3, Yunjie He4

  • 1Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University.

Oncotargets and Therapy
|March 30, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key players in breast cancer drug resistance. Exosomal miRNAs offer promising therapeutic targets and diagnostic biomarkers for overcoming treatment challenges.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer survival rates have improved, but drug resistance and relapse remain significant challenges.
  • MicroRNAs (miRNAs) are implicated in various cancer progression aspects, including drug resistance.
  • Exosomes are emerging as crucial intercellular communication vehicles, transporting functional molecules like miRNAs.

Purpose of the Study:

  • To enumerate functional miRNAs involved in breast cancer drug resistance.
  • To identify miRNA targets and elucidate related mechanisms.
  • To discuss the prospects and challenges of targeting miRNAs and exosomal miRNAs in breast cancer therapy.

Main Methods:

  • Literature review focusing on miRNAs and exosomes in breast cancer drug resistance.
  • Analysis of studies identifying specific miRNAs, their targets, and resistance mechanisms.
  • Discussion of current research and future directions for exosomal miRNA investigation.

Main Results:

  • Numerous miRNAs have been identified as critical regulators of breast cancer drug resistance.
  • Specific miRNA-target interactions and pathways contributing to resistance are elucidated.
  • Exosomal miRNAs play a significant role in mediating intercellular communication and drug resistance.

Conclusions:

  • miRNAs are pivotal in breast cancer progression and drug resistance.
  • Exosomal miRNAs represent a promising avenue for therapeutic intervention and biomarker development.
  • Further research into exosomal miRNA function is crucial for overcoming treatment resistance.
Keywords:
breast cancerdrug resistanceexosomemicroRNA

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