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Integral Roles for Integrins in γδ T Cell Function.

Gabrielle M Siegers1

  • 1Experimental Oncology, University of Alberta, Edmonton, AB, Canada.

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|March 30, 2018
PubMed
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Integrins are crucial cell surface receptors influencing cell behavior. This review details their roles in gamma delta T cell (γδTc) function, including migration and tumor cell killing.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Integrins are cell surface adhesion receptors mediating cell-environment interactions.
  • They are heterodimers composed of α and β glycoprotein chains, crucial for cell signaling and gene expression.
  • Integrin expression and function on gamma delta T cells (γδTc) remain under-investigated.

Purpose of the Study:

  • To systematically review and consolidate existing literature on integrin expression in γδTc.
  • To highlight the diverse roles of integrins in γδTc function.
  • To identify areas for future research regarding integrins and γδTc.

Main Methods:

  • Comprehensive literature review of studies published before December 2017.
  • Analysis of integrin expression on various γδTc subsets (polyclonal, clones, intraepithelial lymphocytes).
  • Comparison of integrin expression between γδTc, αβ T cells, and different γδTc subtypes (Vδ1, Vδ2).

Main Results:

  • Integrins play significant roles in γδTc adhesion, signaling, activation, migration, and tissue localization.
  • Differences in integrin expression exist between γδTc and αβ T cells, and among γδTc subsets.
  • Integrins are implicated in γδTc-mediated functions such as cytokine secretion, tumor infiltration, and tumor cell killing.

Conclusions:

  • Integrins are vital for multiple γδTc functions, extending beyond simple adhesion.
  • Understanding integrin expression patterns can differentiate γδTc subsets and inform their functional roles.
  • Further research is needed to fully elucidate the complex interplay between integrins and γδTc biology.