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Serum Presepsin Levels Are Not Elevated in Patients with Controlled Hypertension

Ismail Biyik1, Fatma Nihan Turhan Caglar2, Nilgun Isiksacan3

  • 1Department of Cardiology, School of Medicine, Education and Research Hospital, Uşak University, Uşak, Turkey.

International Journal of Hypertension
|March 30, 2018
PubMed

Insights

Presepsin (PSP) levels were lower in hypertension patients than controls. This novel inflammation biomarker may be affected by antihypertensive medications, suggesting a link between inflammation and blood pressure management.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Hypertension (HT) is a prevalent condition linked to cardiovascular disease.
  • Inflammation is recognized as a significant factor in HT pathogenesis.
  • Presepsin (PSP), a novel inflammation biomarker, warrants investigation in HT.

Purpose of the Study:

  • To investigate the relationship between presepsin (PSP) levels and hypertension (HT).
  • To explore PSP as a potential biomarker in the context of HT and inflammation.

Main Methods:

  • A comparative study involving 48 patients with controlled HT and 48 healthy controls.
  • Measurement of PSP levels in peripheral venous blood samples.
  • Analysis of routine clinical and laboratory data, including hsCRP and WBC.

Main Results:

  • PSP levels were significantly lower in the HT group compared to controls (p=0.011).
  • PSP showed a positive correlation with hsCRP in both groups (p=0.015 and p=0.009).
  • No significant correlation was found between PSP and WBC in either group.

Conclusions:

  • Presepsin (PSP) levels are not elevated in well-controlled hypertensive patients.
  • Lower PSP levels in HT patients may be influenced by the anti-inflammatory effects of antihypertensive medications.
Abstract

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