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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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Biomarkers in active surveillance.

Stacy Loeb^1,2,3, Jeffrey J Tosoian⁴

¹Department of Urology, New York University, New York, NY, USA.

Translational Andrology and Urology

|March 30, 2018

Summary

Active surveillance for prostate cancer needs better tools. This review covers serum, urine, and tissue markers to improve patient selection and monitoring for active surveillance (AS).

Keywords:

Prostate cancer active surveillance (AS)biomarkers markers

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Area of Science:

Urology
Oncology
Biomarker Research

Background:

Active surveillance (AS) is increasingly used for favorable-risk prostate cancer.
Current clinical staging limitations hinder optimal patient selection for AS.
Serial biopsies for monitoring pose risks like infection and are invasive.

Purpose of the Study:

To review existing evidence on biomarkers for active surveillance in prostate cancer.
To identify markers that can enhance patient selection for AS.
To explore markers for improved monitoring protocols in AS.

Main Methods:

Literature review of studies on serum, urine, and tissue markers.
Analysis of evidence related to biomarker utility in AS selection and monitoring.
Synthesis of current research findings on prostate cancer biomarkers.

Main Results:

Significant interest exists in developing novel markers for AS.
Serum, urine, and tissue markers show potential for improving AS protocols.
Further research is needed to validate these markers for clinical application.

Conclusions:

Biomarkers are crucial for refining active surveillance strategies in prostate cancer.
Improved selection and monitoring via biomarkers can enhance AS efficacy and patient safety.
The reviewed markers offer promising avenues for advancing AS management.