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Updated: Feb 12, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand?
Haitham Mirghani1, Pierre Blanchard2
1Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, France.
Abstract:
HPV-driven oropharyngeal cancers have significantly better survival rates than tobacco and alcohol induced head and neck cancers. As HPV-positive patients are younger, healthier and far more likely to survive their disease, long-term treatment side effects are becoming a major issue. This has led the scientific and medical community to reassess the current treatment protocols in order to develop less toxic strategies while maintaining good oncological outcomes. In this article, we discuss the ongoing treatment de-escalation trials and highlight the issues raised by these studies.
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