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Updated: Jul 25, 2026

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Published on: September 11, 2012
Intestinal motility disorders of infants and children: classification, clinical manifestations and roentgenology
E A Franken1, W L Smith, E E Frey
1Department of Radiology, University of Iowa College of Medicine, Iowa City.
Insights
Pediatric intestinal motility disorders encompass acute, perinatal, and chronic conditions, including paralytic ileus and Hirschsprung
Area of Science:
- Pediatric Gastroenterology
- Intestinal Motility Disorders
- Diagnostic Imaging
Background:
- Intestinal motility disorders present unique challenges in pediatric patients.
- These conditions range from acute paralytic ileus to chronic functional obstructions.
- Understanding pathophysiology and clinical manifestations is crucial for diagnosis.
Purpose of the Study:
- To review the pathophysiology, clinical manifestations, and imaging investigations of pediatric intestinal motility diseases.
- To categorize and describe various acute, perinatal, and chronic motility disorders.
- To highlight diagnostic approaches for these complex conditions.
Main Methods:
- Comprehensive literature review of pediatric intestinal motility disorders.
- Analysis of pathophysiology, clinical presentations, and imaging findings.
- Categorization of diseases based on onset (acute, perinatal, chronic) and etiology.
Main Results:
- Acute conditions include paralytic ileus and regional bowel paralysis.
- Perinatal disorders involve functional intestinal obstruction.
- Chronic disorders are classified as primary bowel abnormalities or secondary to systemic diseases, including Hirschsprung's disease and pseudo-obstruction.
Conclusions:
- Accurate diagnosis of pediatric intestinal motility disorders relies on understanding their diverse pathophysiology and clinical features.
- Appropriate imaging investigations are essential for identifying and characterizing these conditions.
- This review provides a framework for managing pediatric patients with intestinal motility dysfunction.
Abstract:
Diseases affecting intestinal motility in the pediatric age group are reviewed as to pathophysiology, clinical manifestations, and imaging investigation. Acute disease includes classical paralytic ileus (which has unique causes and manifestations in the infant) and acute regional bowel paralysis. Perinatal motility disorders consist of a group of related clinical syndromes which have in common functional intestinal obstruction. Chronic motility disorders are divided into those diseases in which the principal abnormality is in the bowel or those entities where the gut is affected as part of a generalized disease. Regional muscle disease includes Hirschsprung's disease and allied disorders. Some recognized causes of chronic functional obstruction of bowel include megacystis-microcolon-intestinal hypoperistalsis syndrome, rare enzymatic disorders, several discrete forms of chronic intestinal pseudoobstruction, as well as some less well-defined entities. Clinical and pathologic nature and methods of imaging investigation of these entities are considered.
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