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Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles
Sobhi M Gomha1, Mastora M Edress2,3, Zeinab A Muhammad2
1Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Background:
A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.
Results:
In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.
Conclusion:
The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.
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