Related Experiment Video

Updated: Feb 12, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

13.4K

A single-center observational study on the efficacy of percutaneous coronary intervention for ischemic heart failure:

Zongtao Wang1, Lijun Jin, Wanxing Zhou

  • 1The First Affiliated Hospital of Guangdong Pharmaceutical University, School of Clinical Medicine of Guangdong Pharmaceutical University Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science Nanfang Hospital, Southern Medical University, Guangzhou, China.

Medicine
|March 30, 2018
PubMed

Insights

Percutaneous coronary intervention (PCI) improved cardiac function and survival in patients with coronary artery disease (CAD) and heart failure (HF). PCI demonstrated better outcomes than medical treatment alone for these high-risk patients.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Heart Failure Management

Background:

  • Optimal medical treatment is standard for coronary artery disease (CAD) and heart failure (HF).
  • The role of percutaneous coronary intervention (PCI) in addition to optimal medical treatment for CAD and HF requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of PCI on cardiac function and clinical outcomes in patients with CAD and HF receiving optimal medical treatment.
  • To compare outcomes between PCI and optimal medical treatment alone.

Main Methods:

  • A cohort study included 69 patients with CAD and HF.
  • Patients received either optimal medical treatment alone (12 patients) or PCI (57 patients).
  • Outcomes assessed included major adverse cardiovascular events (MACEs), left ventricular ejection fraction (LVEF), and survival rates.

Main Results:

  • PCI significantly improved LVEF compared to medical treatment alone after 3 months.
  • Major adverse cardiovascular events (MACEs) were lower in the PCI group (19.3%) versus the medical treatment group (50%).
  • PCI was associated with significantly better survival rates (P=.02) and a trend towards better survival with complete revascularization.

Conclusions:

  • Percutaneous coronary intervention (PCI) may be an effective strategy for improving survival in patients with CAD and HF.
  • PCI offers significant benefits in cardiac function and clinical outcomes when added to optimal medical treatment.

More Related Videos

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease06:39

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease

Published on: February 18, 2020

7.2K
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

9.1K

Related Concept Videos

Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
545
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
951
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
288