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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Germline Editing: Editors Cautionary.

K Krishan1, T Kanchan2, B Singh3

  • 1Associate Professor and Chair, Department of Anthropology, Panjab University, Sector-14, Chandigarh, India.

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|March 30, 2018
PubMed
Summary
This summary is machine-generated.

Human germline gene editing with CRISPR/Cas9 offers potential cures for genetic disorders but raises concerns about unpredictable effects and ethical implications for future generations and human evolution.

Keywords:
EthicsGeneHuman germline editingHuman society

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Area of Science:

  • Genetics
  • Bioethics
  • Molecular Biology

Background:

  • The advent of CRISPR/Cas9 technology has enabled precise genome editing.
  • Human germline gene modification presents potential therapeutic benefits for genetic diseases.
  • Significant global debate exists regarding the implications of germline gene editing.

Purpose of the Study:

  • To discuss the dual nature of human germline gene editing as both a potential benefit and a concern.
  • To highlight the ethical considerations and potential long-term consequences for the human race.
  • To emphasize the need for caution and stringent regulations in germline gene modification research.

Main Methods:

  • This communication is a discussion based on current scientific understanding and ethical debates.
  • It reviews the potential applications and risks associated with CRISPR/Cas9 in human embryos.
  • It synthesizes expert opinions on the societal and evolutionary impact of germline editing.

Main Results:

  • Human germline gene editing holds promise for treating severe genetic disorders by replacing faulty genes.
  • Unforeseen and unpredictable effects on future generations are a significant concern.
  • The modification of the human germline raises profound ethical questions with implications for human evolution.

Conclusions:

  • Human germline gene modification is a powerful tool with the potential for both great benefit and significant harm.
  • Further in-depth ethical discussions are crucial to navigate the complexities of germline editing.
  • Stringent regulations and cautious approaches are necessary to guide future research and prevent potential conflicts with natural processes.