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The STAR Data Reporting Guidelines for Clinical High Altitude Research.

Monika Brodmann Maeder1,2, Hermann Brugger1, Matiram Pun1

  • 11 Institute of Mountain Emergency Medicine , EURAC Research, Bolzano, Italy .

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The STrengthening Altitude Research (STAR) initiative established uniform reporting guidelines for high-altitude medicine research. Experts identified 42 essential parameters to improve data quality and scientific evidence in the field.

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Area of Science:

  • High-altitude medicine
  • Clinical research methodology
  • Scientific reporting standards

Background:

  • Clinical high-altitude (HA) medicine research requires standardized reporting for improved data quality.
  • The Utstein Style for cardiac arrest research demonstrated the benefits of uniform data protocols.
  • The STrengthening Altitude Research (STAR) initiative aimed to create similar standards for HA medicine.

Purpose of the Study:

  • To develop a uniform set of key elements for clinical high-altitude research and reporting.
  • To enhance the quality and consistency of scientific evidence in HA medicine.

Main Methods:

  • The STAR core group utilized the Delphi method, a consensus-building technique among experts.
  • Experts in clinical HA medicine were selected based on scientific credentials.
  • Multiple rounds of evaluation were conducted to identify essential research parameters.

Main Results:

  • 21 out of 51 identified experts completed the Delphi method rounds.
  • A consensus was reached on 42 key parameters across 5 categories (setting, individual factors, HA cerebral edema, HA pulmonary edema, treatment).
  • An additional 47 supplemental parameters were identified for context-dependent reporting.

Conclusions:

  • The STAR initiative successfully identified essential parameters for clinical HA research and reporting.
  • The Delphi method facilitated expert consensus on these critical data elements.
  • These guidelines aim to strengthen the foundation of scientific evidence in high-altitude medicine.