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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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Skin Rejuvenation through HIF-1α Modulation.

Andrea Pagani1,2, Matthias M Aitzetmüller1,2, Elizabeth A Brett1,2

  • 1Munich, Germany; Stanford, Calif.; Gainesville, Fla.; and Vienna and Linz, Austria.

Plastic and Reconstructive Surgery
|March 30, 2018
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Summary

Aging skin regeneration is impaired by cellular pathway dysfunction. Activating the hypoxia-inducible factor (HIF)-1α pathway can enhance skin repair, collagen production, and vessel formation for rejuvenation.

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Area of Science:

  • Dermatology
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Aging skin exhibits reduced regenerative capacity due to intrinsic and extrinsic stressors.
  • Current rejuvenation methods fail to comprehensively support aging skin's biological processes like collagen synthesis and cell proliferation.
  • Impaired regeneration in aged skin mirrors chronic wound healing, involving dysfunctional cellular regulatory pathways.

Purpose of the Study:

  • To review the role of the hypoxia-inducible factor (HIF)-1α pathway in skin aging and regeneration.
  • To explore how modulating HIF-1α functionality can support skin rejuvenation.
  • To highlight the potential of HIF-1α activation for improving skin homeostasis and tissue repair.

Main Methods:

  • Review of existing scientific literature on skin aging, wound healing, and HIF-1α signaling.
  • Analysis of studies investigating the impact of HIF-1α on cellular processes relevant to skin regeneration.
  • Synthesis of evidence linking HIF-1α pathway dysfunction to impaired skin homeostasis.

Main Results:

  • Dysfunction of the HIF-1α pathway is a key factor in both chronic wounds and aged skin degeneration.
  • HIF-1α signaling is crucial for maintaining tissue homeostasis and promoting neovascularization.
  • Upregulating HIF-1α activity can stimulate the production of collagen, elastin, and new blood vessels.

Conclusions:

  • The HIF-1α pathway is pivotal for tissue regeneration and homeostasis in aging skin.
  • Targeting and enhancing HIF-1α functionality offers a promising strategy for skin rejuvenation.
  • Activating HIF-1α can lead to significant improvements in skin regeneration at both cellular and tissue levels.