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Related Experiment Videos

Does so-called streptozocin hypertension exist in rats?

M Kusaka1, K Kishi, H Sokabe

  • 1Department of Pharmacology, Jichi Medical School, Tochigiken, Japan.

Hypertension (Dallas, Tex. : 1979)
|November 1, 1987
PubMed
Summary

This study investigated streptozocin-induced hypertension in rats. Direct blood pressure measurements revealed that streptozocin does not cause hypertension, contradicting previous indirect measurements.

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Area of Science:

  • Physiology
  • Pharmacology
  • Cardiovascular Research

Background:

  • The existence of streptozocin-induced hypertension is widely accepted.
  • However, some studies report no significant blood pressure increase after streptozocin administration.
  • This discrepancy necessitates a re-evaluation of streptozocin's hypertensive effects.

Purpose of the Study:

  • To accurately assess the impact of streptozocin on blood pressure in different rat models.
  • To compare direct and indirect blood pressure measurement techniques in streptozocin-treated rats.
  • To determine if streptozocin reliably induces hypertension.

Main Methods:

  • Normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were administered streptozocin intravenously.
  • Direct mean blood pressure was measured via abdominal aortic cannula without anesthesia.
  • Indirect tail-cuff blood pressure was measured without anesthesia after prewarming.

Main Results:

  • Indirect blood pressure increased in WKY rats post-streptozocin, but direct measurements showed a decrease.
  • Direct blood pressure in SHR rats decreased significantly after streptozocin treatment.
  • Discrepancies were attributed to rat emaciation affecting indirect BP readings.

Conclusions:

  • Direct blood pressure measurement is more reliable than indirect measurement in emaciated diabetic rats.
  • The findings suggest that "streptozocin hypertension" may not exist under the studied conditions.
  • Streptozocin treatment does not consistently induce hypertension; direct measurement is crucial for accurate assessment.

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