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lncRNA - Long Non-coding RNAs02:39

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Non-Coding RNAs and Endometrial Cancer.

Cristina Vallone1, Giuliano Rigon2, Caterina Gulia3

  • 1Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. cristina.vallone@uslsudest.toscana.it.

Genes
|March 30, 2018
PubMed
Summary

Non-coding RNAs (ncRNAs) play a crucial role in cancer development and progression. This review focuses on the latest research linking various ncRNAs, including long non-coding RNAs (lncRNAs), to endometrial cancer (EC) pathogenesis.

Keywords:
endometrial cancerepigeneticslong non-coding RNA (lncRNA)non-coding RNA (ncRNA)small non-coding RNA (small ncRNA)

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Non-coding RNAs (ncRNAs) regulate cell metabolism and neoplastic transformation.
  • ncRNAs are increasingly recognized for their roles in cancer genesis, progression, and as potential biomarkers.
  • Their significance in lung, bladder, kidney cancers, and melanoma is well-established.

Purpose of the Study:

  • To review recent literature on the role of ncRNAs in oncogenesis.
  • Specifically investigate the relationship between various ncRNAs and endometrial cancer (EC).
  • Identify potential ncRNA targets for EC treatment.

Main Methods:

  • Literature search on PubMed for studies published in the last three years.
  • Extraction and selection of relevant studies by two independent readers.
  • Focus on ncRNAs, general oncogenesis, and endometrial cancer.

Main Results:

  • Numerous ncRNAs, including microRNAs (miRNAs), lncRNAs, and others, are implicated in EC.
  • These molecules influence key cancer processes like growth and invasion.
  • Emerging evidence suggests their potential as therapeutic targets.

Conclusions:

  • ncRNAs are critical players in endometrial cancer development.
  • Further research into ncRNA mechanisms and therapeutic applications is warranted.
  • ncRNAs represent a promising area for EC diagnostics and therapeutics.