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Updated: Feb 12, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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UBE2C Is a Transcriptional Target of the Cell Cycle Regulator FOXM1

Pedro Nicolau-Neto1, Antonio Palumbo2, Marco De Martino3

  • 1Programa de Carcinogênese Molecular, Instituto Nacional de Câncer-INCA, Rua Andre Cavalcanti 37, Rio de Janeiro 20231-050, RJ, Brazil. pedronicolau.n@gmail.com.

Genes
|March 30, 2018
PubMed

Insights

Forkhead box protein M1 (FOXM1) transcriptionally activates the UBE2C gene, which is overexpressed in many cancers. This FOXM1-UBE2C pathway deregulation is a common event in human neoplasias.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • FOXM1 is a key transcription factor regulating cell cycle and proliferation in tumor development.
  • UBE2C, involved in cell cycle progression, is overexpressed in various solid tumors.
  • Both FOXM1 and UBE2C are frequently overexpressed in human cancers.

Purpose of the Study:

  • To determine if UBE2C is a transcriptional target of FOXM1.
  • To investigate the FOXM1-UBE2C regulatory relationship in esophageal squamous cell carcinoma (ESCC) and other cancers.

Main Methods:

  • Correlation analysis of FOXM1 and UBE2C expression in normal and tumor tissues.
  • Chromatin immunoprecipitation (ChIP) assay to assess FOXM1 binding to the UBE2C promoter.
  • Analysis of gene expression data from multiple cancer types.

Main Results:

  • A positive correlation between FOXM1 and UBE2C expression was observed in normal tissues and 25 tumor types, including ESCC.
  • FOXM1 was found to bind to the UBE2C promoter region in an ESCC cell line.
  • FOXM1 transcriptionally activates UBE2C, leading to its upregulation.

Conclusions:

  • FOXM1 directly regulates UBE2C expression at the transcriptional level in ESCC.
  • The observed deregulation of FOXM1 and UBE2C is a widespread phenomenon in human neoplasias.
  • This regulatory axis represents a potential target for cancer therapy.
Keywords:
CancerFOXM1Gene expression controlUBE2C

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