Related Experiment Video
Updated: Feb 12, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
Published on: October 16, 2016
A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
Lea Siegle1,2, Julian D Schwab1,2, Silke D Kühlwein1,2
1Institute of Medical Systems Biology, Ulm University, Ulm, Germany.
Abstract:
Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.
Related Concept Videos
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathways
What is Cell Signaling?
Satellite Stem Cells and Muscular Dystrophy
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Cell-surface Signaling

