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The characteristics of premature infants with transient corneal haze

Yu-Hung Lai1,2,3, Hsiu-Lin Chen4,5, San-Nan Yang6

  • 1Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Plos One
|March 30, 2018
PubMed

Insights

Transient corneal haze in premature infants is linked to lower birth weight and older maternal age. These infants may need closer clinical attention and monitoring for retinopathy of prematurity (ROP).

Area of Science:

  • Neonatal Ophthalmology
  • Perinatal Medicine

Background:

  • The causes of transient corneal haze in premature infants remain unknown.
  • The relationship between corneal haze and clinical outcomes in this population is unclear.

Purpose of the Study:

  • To investigate factors associated with transient corneal haze in premature infants.
  • To identify predictors of corneal haze in neonates.

Main Methods:

  • Retrospective analysis of 261 premature infants undergoing retinopathy of prematurity (ROP) screening.
  • Statistical analyses including correlation tests, Chi-square tests, and logistic regressions were employed.
  • Evaluation of associations between corneal haze and birth weight, gestational age, central corneal thickness, intraocular pressure, and other clinical data.

Main Results:

  • Corneal haze incidence was 13.4% in the study cohort.
  • Associated factors included lower birth weight, lower gestational age, packed red blood cell transfusion, prolonged oxygen use, older maternal age, bronchopulmonary disease, and stage 3 ROP.
  • Lower birth weight and older maternal age were identified as the most significant predictors of corneal haze.

Conclusions:

  • Lower birth weight and older maternal age are key predictors of transient corneal haze in premature infants.
  • Infants with corneal haze may have increased risks for systemic and ocular morbidities, warranting closer clinical observation.
  • While unlikely to impede ROP treatment, corneal haze might complicate ROP screening, necessitating careful follow-up protocols.
Abstract

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