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Circulating parathyroid hormone and risk of hypertension: A meta-analysis
1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Objectives:
To examine the relationship between circulating parathyroid hormone (PTH) level and risk of hypertension (HTN).
Methods:
The electronic databases of PubMed, Web of Science and Embase were searched up to December 2017, for prospective cohort studies on the relationship between circulating PTH level and risk of HTN. The pooled relative risk (RR) of HTN for the highest versus lowest category of circulating PTH level as well as their corresponding 95% confidence interval (CI) were calculated.
Results:
A total of six prospective cohort studies, which involved 18,994 participants and 5040 HTN cases, were included in this meta-analysis. The overall multi-variable adjusted RR showed a positive relationship between circulating PTH level and risk of HTN (RR = 1.35, 95%CI: 1.09 to 1.67; P = 0.006). A substantial level of heterogeneity was observed among the studies (P < 0.001, I2 = 77.6%). No evidence of publication bias was observed among the studies according to Begg's rank-correlation test (P = 0.452).
Conclusions:
The existing evidence suggests that an increase in circulating PTH level may be associated with a higher risk of HTN. However, due to the limited number of included studies, more well-designed prospective cohort studies are needed to further elaborate the issues examined in this study.
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