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Updated: Feb 12, 2026
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Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
21.7K
Complement-fixing donor-specific anti-HLA antibodies and kidney allograft failure
Helena B Cazarote1, Silvia Shimakura2, Joana S Valdameri3
1Transplant Immunology Laboratory, Hospital Universitário Cajuru, Curitiba, PR, Brazil; School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Transplant Immunology
|March 30, 2018
Summary
Detecting complement-binding donor-specific antibodies (DSA) after kidney transplant improves risk assessment. Patients with C1q-binding DSA face lower graft survival and reduced kidney function, highlighting its clinical impact.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- Donor-specific antibodies (DSA) are crucial for risk stratification in kidney transplant recipients.
- Assessing DSA C1q-binding ability enhances risk classification for allograft loss, particularly post-transplant.
Purpose of the Study:
- To evaluate the added clinical value of detecting C1q-binding DSA in a well-monitored kidney transplant population.
- To assess the impact of C1q-binding DSA on long-term allograft survival and function.
Main Methods:
- Follow-up of 42 kidney allograft recipients for up to 5 years post-transplant.
- Detection of anti-HLA DSA-IgG total and retrospective testing for complement-binding antibodies (C1q-binding DSA).
- Comparison of allograft survival and estimated glomerular filtration rate (eGFR) between patient groups.
Main Results:
- 24 patients (57%) had DSA; 7 of these (29%) exhibited complement-binding DSA.
- Patients with C1q-binding DSA showed significantly lower 5-year allograft survival rates (p=0.042).
- C1q-binding DSA positivity was associated with lower eGFR during follow-up (p=0.01).
Conclusions:
- Post-transplant monitoring for C1q-binding DSA is valuable for identifying patients at high risk of allograft failure.
- This monitoring may aid in optimizing immunosuppression strategies for kidney transplant recipients.
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