Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

48.4K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Convergent Evolution01:54

Convergent Evolution

33.1K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
33.1K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.5K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.5K
Eukaryotic Evolution01:24

Eukaryotic Evolution

42.4K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
42.4K
Synteny and Evolution02:31

Synteny and Evolution

3.8K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.0K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Length of hospital and intensive care unit stay in patients with invasive candidiasis and/or candidemia treated with rezafungin: a pooled analysis of two randomised controlled trials.

Critical care (London, England)·2024
Same author

Propofol curtails survival in perioperative and critically ill patients by a relative reduction of 10%: should propofol be abandoned?

Annals of translational medicine·2024
Same author

Exploring volanesorsen: a promising approach to preventing acute pancreatitis in severe hypertriglyceridemia.

Annals of translational medicine·2024
Same author

Has the CONVINCE trial convinced the nephrology and dialysis community?

Annals of translational medicine·2024
Same author

Optimizing endovascular thrombectomy timing and thrombolysis use for ischemic stroke: insights from the SELECT2 and TIMELESS trials.

Annals of translational medicine·2024
Same author

Rezafungin versus caspofungin for patients with candidaemia or invasive candidiasis in the intensive care unit: pooled analyses of the ReSTORE and STRIVE randomised trials.

Critical care (London, England)·2024

Related Experiment Video

Updated: Feb 12, 2026

Author Spotlight: Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model
08:51

Author Spotlight: Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

Published on: March 31, 2023

5.5K

Evolution of Vascular Access and Anticoagulation.

Patrick M Honore, Herbert D Spapen

    Contributions to Nephrology
    |March 30, 2018
    PubMed
    Summary

    Continuous renal replacement therapy (CRRT) requires proper vascular access and anticoagulation. Regional citrate anticoagulation (RCA) offers advantages over unfractionated heparin (UFH) but needs careful monitoring for metabolic effects.

    Area of Science:

    • Nephrology
    • Critical Care Medicine

    Background:

    • Continuous renal replacement therapy (CRRT) is vital for critically ill patients.
    • Effective CRRT depends on appropriate vascular access and circuit anticoagulation.

    Purpose of the Study:

    • To review vascular access options and anticoagulation strategies for CRRT.
    • To compare unfractionated heparin (UFH) with regional citrate anticoagulation (RCA).

    Main Methods:

    • Review of current literature on CRRT vascular access and anticoagulation.
    • Comparison of UFH and RCA efficacy, safety, and circuit survival.

    Main Results:

    • Right internal jugular vein is preferred for CRRT access; femoral veins are alternatives.
    • RCA offers improved circuit survival and safety in bleeding-risk patients compared to UFH.

    More Related Videos

    A Murine Model of Hemodialysis Access-Related Hand Dysfunction
    08:39

    A Murine Model of Hemodialysis Access-Related Hand Dysfunction

    Published on: May 31, 2022

    2.1K
    Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
    07:08

    Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

    Published on: September 5, 2017

    8.9K

    Related Experiment Videos

    Last Updated: Feb 12, 2026

    Author Spotlight: Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model
    08:51

    Author Spotlight: Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

    Published on: March 31, 2023

    5.5K
    A Murine Model of Hemodialysis Access-Related Hand Dysfunction
    08:39

    A Murine Model of Hemodialysis Access-Related Hand Dysfunction

    Published on: May 31, 2022

    2.1K
    Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
    07:08

    Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

    Published on: September 5, 2017

    8.9K
  • RCA necessitates monitoring for metabolic disturbances.

    • Conclusions:

    • Vascular access and anticoagulation are critical for CRRT success.
    • RCA represents a significant advancement in CRRT anticoagulation, despite requiring vigilant monitoring.
    • Future research should focus on improved catheter technology and citrate solutions.