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Vitamin D and Diabetes Mellitus
Frontiers of Hormone Research
|March 30, 2018
Summary
Vitamin D
Area of Science:
- Endocrinology
- Immunology
- Metabolic Diseases
Background:
- Vitamin D's potential role in diabetes mellitus is supported by immune response regulation and epidemiological data linking adequate levels to reduced type 1 diabetes risk.
- Emerging evidence suggests vitamin D influences insulin secretion and sensitivity, implicating it in glucose homeostasis for pre-diabetes and type 2 diabetes (T2D).
Purpose of the Study:
- To review the rationale and findings of randomized clinical trials (RCTs) investigating vitamin D and its analogs for autoimmune and type 2 diabetes.
Main Methods:
- Review of existing literature focusing on randomized clinical trials (RCTs) evaluating vitamin D supplementation in autoimmune diabetes and type 2 diabetes (T2D).
Main Results:
- Clinical trials on vitamin D supplementation for autoimmune diabetes have yielded disappointing results, despite theoretical underpinnings.
- RCTs assessing vitamin D's efficacy in managing glucose homeostasis for type 2 diabetes (T2D) have produced inconsistent outcomes.
Conclusions:
- Current evidence from randomized clinical trials does not strongly support vitamin D supplementation for managing autoimmune diabetes or consistently for type 2 diabetes (T2D).
- Further well-powered studies may be needed to clarify vitamin D's precise role in diabetes pathogenesis and management.
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