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Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness

Rossella Farra1, Francesco Musiani2, Francesca Perrone3

  • 1Department of Engineering and Architecture, University of Trieste, Via Alfonso Valerio, 6/A, I-34127 Trieste, Italy. rfarra@units.it.

Molecules (Basel, Switzerland)
|March 31, 2018
PubMed

Insights

Developing targeted drug delivery systems using small interfering RNAs (siRNAs) and polymers can improve hepatocellular carcinoma (HCC) treatment. This approach enhances drug specificity for better therapeutic outcomes in HCC patients.

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Oncology and Cancer Therapy
  • Drug Delivery Systems

Background:

  • Current anticancer therapies often lack optimal effectiveness for many human tumors, including hepatocellular carcinoma (HCC).
  • Enhancing drug specificity is crucial for improving treatment efficacy, necessitating targeted delivery systems.
  • Nucleic acid-based drugs (NABDs), particularly small interfering RNAs (siRNAs), offer gene-specific targeting capabilities.

Purpose of the Study:

  • To review recent advancements in siRNA/polymeric targeted delivery systems for hepatocellular carcinoma (HCC).
  • To identify promising siRNA-polymer combinations tailored to HCC's biological characteristics.
  • To explore mathematical modeling for optimizing siRNA-carrier delivery mechanisms and enhancing therapeutic effectiveness.

Main Methods:

  • Focus on recent findings in selecting siRNA and polymeric carriers for HCC targeted delivery.
  • Analysis of promising siRNA-polymer combinations based on HCC tissue-specific biological features.
  • Inclusion of mathematical descriptions for siRNA-carrier delivery mechanisms to guide experimental work.

Main Results:

  • Emerging polymeric systems show versatility as carriers for tumor-targeted delivery.
  • siRNAs can be engineered for specific targeting of tumor genes, enhancing drug specificity.
  • Mathematical modeling aids in understanding and improving the efficiency of siRNA delivery systems.

Conclusions:

  • siRNA/polymeric targeted delivery systems represent a promising strategy for improving HCC treatment efficacy.
  • Tailoring delivery systems to HCC's biological features and employing mathematical modeling can optimize therapeutic outcomes.
  • This approach holds potential for more effective and less experimentally intensive cancer therapies.
Keywords:
HCCoptimized drug deliverysiRNA

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