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Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii
Thi Quynh Do1, Bich Ngan Truong1, Huong Doan Thi Mai1
1a Advanced Center for Bioorganic Chemistry , Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi 100000 , Vietnam.
Abstract:
Four new compounds N-salicyl-3-hydroxyanthranilic acid methyl ester (1), N-(2'-dehydroxysalicyl)-3-hydroxyanthranilic acid methyl ester (2), methyl-4-β-D-allopyranosyl-ferulate (3), and methyl-4-β-D-gulopyranosyl-cinnamate (4), along with six known compounds (5-10), were isolated from the roots of Aconitum carmichelii Debx. Their structures were elucidated on the basis of spectral data analysis, including 1D, 2D-NMR, and HR-ESI-MS. Compounds 1 and 2 showed the inhibition of nitric oxide (NO) production with IC50 values of 9.13 and 19.94 μM, respectively.
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