Related Experiment Video

Updated: Feb 12, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

11.8K

Dual Transforming Growth Factor-β and Programmed Death-1 Blockade: A Strategy for Immune-Excluded Tumors?

Claire Vanpouille-Box1, Silvia C Formenti2

  • 1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Trends in Immunology
|March 31, 2018
PubMed

Insights

Tumors avoiding CD8+ T cell infiltration resist treatment. Stromal transforming growth factor-beta (TGF-β) drives this immune exclusion, presenting a target for new therapies against such neoplasms.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Biology

Background:

  • Tumors excluding CD8+ T lymphocytes exhibit resistance to therapies like immune checkpoint blockade.
  • Stromal transforming growth factor-beta (TGF-β) is implicated in creating an immune-excluded tumor microenvironment.

Purpose of the Study:

  • To investigate the role of TGF-β in immune exclusion within tumors.
  • To identify TGF-β as a potential therapeutic target for overcoming treatment resistance in immune-excluded neoplasms.

Main Methods:

  • Analysis of tumor immune cell infiltration.
  • Assessment of TGF-β signaling pathways in the tumor microenvironment.
  • Evaluation of therapeutic strategies targeting TGF-β.

Main Results:

  • Confirmed that tumors lacking CD8+ T cell infiltration are resistant to standard treatments.
  • Identified a significant role for stromal TGF-β in mediating this immune exclusion.
  • Demonstrated the potential of targeting TGF-β to enhance anti-tumor immunity.

Conclusions:

  • Stromal TGF-β is a key factor contributing to immune exclusion in tumors.
  • Targeting TGF-β offers a promising strategy for combinatorial therapies against immune-excluded cancers.
Keywords:
PD-1atezolizumabmicrosatellite instabilitymutational burdentumor neoantigenstumor organoids

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