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Updated: Feb 12, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
Experimental and numerical study of platelets rolling on a von Willebrand factor-coated surface
Justine S Pujos1, Mathilde Reyssat1, Anne Le Goff2
1ESPCI Paris, PSL Research University, CNRS UMR 7083 Gulliver, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Abstract:
Blood platelets circulate in the blood and adhere to wounded vessels to initiate coagulation and healing. The first step of this process is the capture of flowing platelets by adhesive molecules located at the wounded vessel wall. In this article, we study the transport of fixed blood platelets in a microfluidic channel coated with von Willebrand factor (vWF), a large multimeric protein expressed by endothelial cells in the vicinity of wounds. We measure the number of platelets adsorbed at the channel surface as a function of both time and space. Experimental results are compared with a new transport model. We show that transverse diffusion is an important feature of our model, while the rolling behaviour of the bounded platelets can be neglected.
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