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No Relation between Psoriasis and Renal Abnormalities: A Case-Control Study.

Zohreh Tehranchinia1, Esmat Ghanei2, Nahid Mohammadi1

  • 1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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|March 31, 2018
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Summary
This summary is machine-generated.

Psoriasis patients without other health issues show no increased risk of kidney disease. This study found no significant differences in renal abnormalities between psoriasis patients and controls, suggesting no direct link in the absence of comorbidities.

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Area of Science:

  • Nephrology
  • Dermatology
  • Clinical Research

Background:

  • Psoriasis is a chronic inflammatory disease with potential systemic manifestations.
  • Previous studies suggest an association between psoriasis and kidney disease (nephropathy), but evidence is debated.
  • The specific risk of renal abnormalities in psoriasis patients, independent of other conditions, requires further investigation.

Purpose of the Study:

  • To determine if patients with moderate to severe chronic plaque psoriasis have an elevated risk of renal abnormalities.
  • To assess renal function in psoriatic patients excluding those with common comorbidities like diabetes, hypertension, or pre-existing kidney disease.
  • To compare urinalysis, proteinuria, and albuminuria levels between psoriatic patients and matched controls without comorbidities.

Main Methods:

  • A case-control study involving 40 patients with moderate to severe chronic plaque psoriasis and 40 age- and gender-matched controls.
  • Exclusion criteria included history of diabetes, hypertension, and chronic renal disease for both groups.
  • Standard urinalysis (dipstick and microscopic), 24-hour proteinuria, and 24-hour albuminuria were performed on all participants.

Main Results:

  • No significant difference was observed in the prevalence of abnormal urinalysis between psoriasis patients (7.5%) and controls (5%) (P = 1.0).
  • Mean 24-hour proteinuria levels were similar: 70.40 ± 24.38 mg/24h in psoriasis patients versus 89.40 ± 26.78 mg/24h in controls (P = 0.30).
  • Mean 24-hour albuminuria levels were also comparable: 14.15 ± 8.12 mg/24h in psoriasis patients versus 16.62 ± 8.21 mg/24h in controls (P = 0.18).

Conclusions:

  • Psoriatic patients without comorbidities such as diabetes, hypertension, or chronic kidney disease do not exhibit an increased risk of renal abnormalities.
  • The study findings suggest that common renal issues observed in psoriasis may be linked to these frequently co-occurring conditions rather than psoriasis itself.
  • Further research may be warranted to explore the specific mechanisms linking psoriasis and renal health when comorbidities are present.