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Updated: Feb 12, 2026

A Murine Model of Subarachnoid Hemorrhage
07:40

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

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Treatment Modality and Quality Benchmarks of Aneurysmal Subarachnoid Hemorrhage at a Comprehensive Stroke Center

Wengui Yu1,2,3, Tapan Kavi1,4, Tamara Majic1

  • 1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Frontiers in Neurology
|March 31, 2018
PubMed

Insights

Comprehensive Stroke Centers (CSCs) provide high-quality care for aneurysmal subarachnoid hemorrhage (aSAH). Early CSCs demonstrated fast treatment, low rebleeding rates, and good patient outcomes for aSAH.

Area of Science:

  • Neurology
  • Neurosurgery
  • Public Health

Background:

  • Aneurysmal subarachnoid hemorrhage (aSAH) represents a severe stroke type.
  • Comprehensive Stroke Centers (CSCs) were established to enhance care for complex stroke patients.
  • This study evaluates aSAH management at an early CSC.

Purpose of the Study:

  • To assess treatment modalities and quality benchmarks for aSAH.
  • To analyze outcomes at one of the first certified CSCs in the U.S.

Main Methods:

  • Retrospective analysis of 118 aSAH patients (2012-2014).
  • Aneurysm treatment via coiling or clipping within 24 hours.
  • Evaluation of treatment rates, door-to-treatment times, rebleeding, length of stay (LOS), and mortality.

Main Results:

  • 95% aneurysm treatment rate with a median door-to-treatment time of 12.5 hours.
  • Low posttreatment rebleed rate (0.9%) and median hospital LOS of 17 days.
  • 50% favorable outcomes and 16.1% mortality; coiling showed shorter LOS than clipping.

Conclusions:

  • Early CSCs achieved high aSAH treatment rates, rapid intervention, and low mortality.
  • Coiling resulted in shorter hospital LOS compared to clipping.
  • No significant difference in discharge outcomes between coiling and clipping.
Abstract

Keywords:
aneurysmclippingcoilingdoor-to-treatment timelength of staymortality rateoutcomesubarachnoid hemorrhage

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