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Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

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Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques.

Yue Li¹, Tzu-Ming Liu¹

¹Faculty of Health Sciences, University of Macau, Macao, China.

Frontiers in Immunology

|March 31, 2018

Summary

This review explores how in vivo optical imaging enhances understanding of macrophage dynamics in diseases like cancer and diabetes. It highlights advances and challenges in tracking these vital immune cells for improved diagnostics and therapeutics.

Keywords:

bioluminescence imaging cell tracking function intravital microscopy macrophage optical imaging

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Area of Science:

Immunology
Cell Biology
Medical Imaging

Background:

Macrophages are crucial for host defense, inflammation, and tissue regulation.
Their versatile functions link them to numerous diseases, including cancer, diabetes, and atherosclerosis.
Current understanding of in vivo macrophage dynamics is limited despite advances in molecular and histological methods.

Purpose of the Study:

To review advancements in tracking and analyzing macrophage behavior using in vivo optical imaging.
To explore the application of these techniques in various disease contexts.
To discuss challenges and solutions associated with intravital imaging of macrophages.

Main Methods:

In vivo optical imaging techniques for macrophage tracking.
Analysis of dynamic macrophage behaviors in living organisms.
Review of current literature on intravital imaging in disease models.

Main Results:

Optical imaging provides critical insights into macrophage functions and dynamics in vivo.
These techniques are advancing the understanding of macrophage roles in pathogenesis.
Challenges in intravital imaging include signal penetration, phototoxicity, and motion artifacts.

Conclusions:

Improved understanding of macrophage dynamics via in vivo imaging offers new diagnostic and therapeutic avenues.
Overcoming technical challenges in optical imaging is key to further discoveries.
Intravital imaging is essential for unraveling macrophage roles in health and disease.