Related Experiment Video

Updated: Feb 12, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.9K

Prevalence of chronic viral hepatitis infections in Karaj, Iran

Kourosh Kabir1, Hassan Hoseini2,3, Mohammad Miri2,3

  • 1Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran.

The Pan African Medical Journal
|March 31, 2018
PubMed

Insights

Prevalence of hepatitis B (HBV) and hepatitis C (HCV) in Karaj blood donors is low. HBV infection rates decreased significantly between 2010-2013, while HCV rates remained stable. Educational level impacted infection risk.

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • Viral hepatitis poses significant challenges to public health and blood safety.
  • Blood donor studies are crucial for monitoring hepatitis B (HBV) and hepatitis C (HCV) infection trends.
  • Understanding prevalence aids in ensuring blood donation safety.

Purpose of the Study:

  • To determine the prevalence of HBV and HCV infections among blood donors in Karaj.
  • To analyze infection trends over a four-year period (2010-2013).

Main Methods:

  • Cross-sectional seroepidemiological study design.
  • Data collected from blood donor registries, including demographic characteristics.
  • Statistical analysis using Chi-square and logistic regression with 95% confidence intervals.

Main Results:

  • Overall HBV prevalence was 0.40% and HCV prevalence was 0.18%.
  • First-time donors with primary education had a 3.59-fold higher risk of HBV and 4.8-fold higher risk of HCV compared to those with academic education.
  • A significant decrease in HBV frequency (P<0.001) was observed over the study period, while HCV frequency remained statistically unchanged.

Conclusions:

  • Karaj blood donor population exhibits low frequencies of HBV and HCV infections.
  • Infection rates were found to be equal between genders.
  • Findings are essential for developing targeted strategies to control viral hepatitis transmission.
Abstract

Keywords:
Hepatitis BHepatitis CIranblood safetyprevalence

More Related Videos

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

10.7K

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.8K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
281
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
6.3K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
250