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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Self-Concept01:19

Self-Concept

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Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
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Bone as Supporting Connective Tissue01:23

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Concepts and Prototypes01:24

Concepts and Prototypes

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The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
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Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
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Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

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Current Concepts in Scaffolding for Bone Tissue Engineering.

Toktam Ghassemi1,2,3, Azadeh Shahroodi1,2,3, Mohammad H Ebrahimzadeh1,2,3

  • 1Department of Chemical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.

The Archives of Bone and Joint Surgery
|March 31, 2018
PubMed
Summary
This summary is machine-generated.

Bone tissue engineering using scaffolds shows promise for treating bone defects. Biomaterials require modifications for improved porosity, strength, and cell response for effective bone regeneration.

Keywords:
Bone tissue engineeringRegenerationScaffolds

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Area of Science:

  • Biomaterials Science
  • Orthopedic Medicine
  • Tissue Engineering

Background:

  • Bone disorders are increasingly prevalent, particularly in middle-aged populations.
  • Scaffold-based bone tissue engineering offers a promising therapeutic approach for osseous defects.
  • Next-generation orthopedic medicine utilizes porous composite materials and functional coatings for implants.

Purpose of the Study:

  • To review studies on bone tissue engineering from a biomaterial perspective, focusing on scaffolding.
  • To highlight the potential of various biomaterials, including osteoconductive and osteoinductive options.
  • To identify necessary physiochemical modifications for enhanced scaffold performance.

Main Methods:

  • Review of existing literature on bone tissue engineering scaffolds.
  • Analysis of biomaterials used in orthopedic applications.
  • Evaluation of material properties relevant to bone regeneration.

Main Results:

  • Osteoconductive (e.g., hydroxyapatite, tricalcium phosphate) and osteoinductive (e.g., demineralized bone matrix) materials are explored.
  • Significant interest in bone derivatives for their osteoinductive potential.
  • Physiochemical modifications are crucial for optimizing porosity, mechanical strength, and biological interactions.

Conclusions:

  • Biomaterial selection and modification are critical for successful bone tissue engineering.
  • Scaffolds require tailored properties to enhance cell adhesion, proliferation, mineralization, and osteogenic differentiation.
  • Further research into material optimization is needed for advanced orthopedic therapies.