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Updated: Feb 12, 2026
11:51
Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
Published on: March 2, 2011
15.7K
A new 2% testosterone gel formulation: a comparison with currently available topical preparations
S Arver1, C Stief2, J de la Rosette3
1Karolinska Institute, Stockholm, Sweden.
Andrology
|March 31, 2018
Summary
Testosterone gels effectively treat hypogonadism by restoring levels and improving quality of life. While generally safe, secondary exposure risk exists, with new formulations offering improved application.
Area of Science:
- Endocrinology
- Dermatology
- Pharmacology
Background:
- Testosterone gel formulations are a popular choice for testosterone replacement therapy (TRT) in hypogonadal patients.
- These gels restore testosterone to physiological levels within 24 hours, alleviating deficiency symptoms and improving quality of life.
- Compared to injections and patches, gels offer a favorable efficacy and safety profile, though secondary exposure remains a concern.
Purpose of the Study:
- To provide a comprehensive review of existing and emerging testosterone gel formulations.
- To analyze pharmacokinetic, tolerability, and safety profiles of marketed testosterone gels.
- To evaluate the novel 2% testosterone gel, Testavan, including its formulation and application features.
Main Methods:
- Literature review of approved testosterone gel formulations (Tostrex, Androgel, Testim, Axiron).
- Analysis of pharmacokinetic data, tolerability, and safety profiles.
- Review of Testavan's novel hydroalcoholic, viscous formulation, metered dose dispenser, and cap applicator for hands-free application.
Main Results:
- Approved testosterone gels demonstrate favorable efficacy and positively impact patient-reported outcomes.
- Testavan, a 2% testosterone gel, features a novel formulation and applicator for precise, hands-free application.
- The review covers pharmacokinetic, tolerability, and safety data for both established and new testosterone gels.
Conclusions:
- Testosterone gels are effective TRT options with good efficacy and safety profiles.
- Newer formulations like Testavan aim to mitigate risks such as secondary exposure through innovative delivery systems.
- Comprehensive understanding of these formulations aids in optimizing hypogonadism management.
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