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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The Hyoid Bone01:12

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The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
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Related Experiment Video

Updated: Feb 12, 2026

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
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Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

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3D bone models to study the complex physical and cellular interactions between tumor and the bone microenvironment.

Joseph P Vanderburgh1,2, Scott A Guelcher1,2,3,4, Julie A Sterling1,3,4,5

  • 1Vanderbilt Center for Bone Biology, Nashville, Tennessee.

Journal of Cellular Biochemistry
|March 31, 2018
PubMed
Summary

Developing advanced 3D bone models is crucial for understanding tumor-bone interactions and drug responses. These models better mimic the in vivo environment, improving research accuracy.

Keywords:
3D bone modelsbone architecturebone destructioncancer and bone

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Area of Science:

  • Biomaterials Science
  • Cancer Biology
  • Tissue Engineering

Background:

  • The tumor microenvironment's complexity necessitates advanced in vitro models.
  • Traditional 2D cell culture models fail to replicate in vivo conditions.
  • 3D models offer a more accurate representation of the native tissue milieu.

Purpose of the Study:

  • To review current 3D bone microenvironment models.
  • To highlight challenges in developing accurate bone tissue models.
  • To emphasize the importance of mechanical signaling in bone and tumor cell behavior.

Main Methods:

  • Focus on engineering 3D models that replicate bone rigidity and architecture.
  • Investigate materials and fabrication processes for complex tissue models.
  • Explore methods to support multiple cell populations within the 3D model.

Main Results:

  • Accurate 3D bone models are essential for understanding signaling pathways.
  • Model properties like architecture and rigidity significantly impact cell response.
  • Improved models facilitate better comprehension of bone turnover and drug efficacy.

Conclusions:

  • 3D bone microenvironment models are critical for advancing cancer research.
  • Material selection and mechanical properties are key factors in model development.
  • Accurate in vitro models improve the study of tumor-bone interactions and therapeutic responses.