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Pelvic Artery Calcification Score Is a Marker of Vascular Calcification in Male Hemodialysis Patients
Tomohiko Matsuura1, Takaya Abe1, Mitsutaka Onoda1
1Department of Urology, Iwate Medical University School of Medicine, Morioka, Japan.
Insights
Pelvic artery calcification scores (PACS) offer a novel method for evaluating vascular calcification in hemodialysis patients. This approach may overcome limitations of traditional coronary artery calcification scores in this population.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Patients undergoing hemodialysis have a high prevalence of cardiovascular disease (CVD).
- Coronary artery calcification (CAC) scoring is crucial for CVD risk assessment but can be inaccurate in hemodialysis patients due to severe calcification.
- A calcification evaluation method specific to hemodialysis patients is needed.
Purpose of the Study:
- To investigate pelvic artery calcification scores (PACS) as a potential marker for vascular calcification in hemodialysis patients.
- To compare PACS in hemodialysis patients versus controls with normal renal function.
Main Methods:
- Utilized 64-row multi-slice CT to assess pelvic artery calcification.
- Applied the Agatston method for calculating both coronary artery calcification scores (CACS) and PACS.
- Compared male patients undergoing hemodialysis with male patients of normal renal function.
Main Results:
- Hemodialysis patients showed a significantly higher incidence of pelvic artery calcification (79.7%) compared to controls (5.5%).
- A correlation was observed between PACS and CACS, and between PACS and dialysis duration.
- Penile artery calcification was also more prevalent in hemodialysis patients.
Conclusions:
- Pelvic artery calcification is highly prevalent in hemodialysis patients.
- PACS, quantifiable via the Agatston method, shows potential as a reliable vascular calcification evaluation tool for hemodialysis patients.
- PACS may serve as a valuable alternative for assessing vascular calcification in this high-risk group.
Abstract:
Patients who undergo hemodialysis often suffer from cardiovascular disease (CVD), and evaluation of coronary artery calcification is extremely important. These evaluations are typically conducted using a noninvasive method including electron beam computed tomography (CT) or multi-detector CT, and the Agatston method to calculate the coronary artery calcification score (CACS). However, it is difficult to use for patients undergoing dialysis. Because patients undergoing dialysis is too strong in coronary artery calcification, and results become incorrect. Therefore, we were looking for a calcified evaluation place peculiar to a patients undergoing dialysis. We obtained pelvic artery calcification scores (PACS) using a 64-row multi-slice CT to assess the presence of calcification within a triangular space bordered by bordered by osseous structure. We used the Agatston method to calculate PACS. We compared male patients undergoing dialysis with male patients with normal renal function. Patients undergoing hemodialysis had a significantly higher incidence of pelvic artery calcification than normal controls (79.7% vs. 5.5%). In the dialysis group, CACS was 1660.2 (0-9056.1), and PACS was 48.8 (0-2943.1). We found a correlation between PACS and CACS and between PACS and dialysis period. We found penile artery calcification in male patients undergoing hemodialysis was more than normal controls, and it was possible to quantify PACS using the Agatston method. This study suggested the possibility that PACS became the vascular calcification evaluation method of the hemodialysis patient.
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