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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Published on: May 27, 2015

Five macrocyclic glycosides from Schoenoplectus tabernaemontani.

Dian Peng¹, Xiaolin Lin², Lin Jiang³

¹a Xiangya School of Pharmaceutical Sciences, Central South University , Changsha , China.

Natural Product Research

|March 31, 2018

Summary

Researchers isolated five macrocyclic glycosides, including three novel compounds, from Schoenoplectus tabernaemontani. Berchemolide (4) demonstrated anti-oxidative activity in kidney cells, highlighting potential therapeutic applications.

Keywords:

Cyperaceae macrocyclic glycosides natural products

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Area of Science:

Natural Product Chemistry
Pharmacology

Background:

Macrocyclic glycosides with 22-membered dimeric lactone skeletons are rare natural products, with only ten previously reported.
Schoenoplectus tabernaemontani is a plant species that may contain novel bioactive compounds.

Purpose of the Study:

To isolate and characterize new macrocyclic glycosides from Schoenoplectus tabernaemontani.
To evaluate the anti-oxidative properties of isolated compounds.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation through extensive spectroscopic data analysis (NMR, MS).
In vitro evaluation of anti-oxidative activity using H2O2-induced oxidative stress in HK-2 cells.

Main Results:

Five macrocyclic glycosides were isolated from Schoenoplectus tabernaemontani.
Three new compounds, Schoenopolide A-C (1-3), were identified.
Two known compounds, Berchemolide (4) and Clemoarmanoside B (5), were also isolated.
Berchemolide (4) exhibited anti-oxidative activity against H2O2-induced oxidative stress in renal tubular epithelial (HK-2) cells.

Conclusions:

Schoenoplectus tabernaemontani is a source of rare macrocyclic glycosides.
The newly identified compounds Schoenopolide A-C expand the known diversity of this chemical class.
Berchemolide (4) shows potential as an anti-oxidative agent for renal protection.