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Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.
Published on: June 27, 2025
A new flavonoid from the leaves of Atalantia monophylla (L.) DC
Priyapan Posri1, Jittra Suthiwong1, Pitchayakarn Takomthong2
1a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
Abstract:
A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4'-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer's disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman's method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.
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