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CRISPR-Cas9-Mediated Genome Editing in the Filamentous Ascomycete Huntiella omanensis
Published on: June 9, 2020
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Pigments from Filamentous Ascomycetes for Combination Therapy
Róbert Hromádka1, Zdeněk Kejík2, Milan Jakubek3,4
1C2P s.r.o. Jungmannova 101 503 51 Chlumec nad Cidlinou, Czech Republic.
Current Medicinal Chemistry
|March 31, 2018
Summary
Filamentous ascomycetes produce valuable secondary metabolites for medicine. Combining these compounds with other therapies can improve efficacy and reduce side effects for treating diseases like cancer and hyperlipidaemia.
Area of Science:
- Mycology
- Medicinal Chemistry
- Pharmacology
Background:
- Filamentous ascomycetes, including Neurospora and Monascus, are known for producing secondary metabolites like microbial pigments.
- These ascomycetes yield compounds with significant medicinal potential, showing efficacy against oncological diseases, neurodegenerative disorders, and hyperlipidaemia.
Purpose of the Study:
- To review and discuss the principles of using ascomycete compounds in combination therapy.
- To explore strategies for overcoming the limited clinical usability of ascomycete-derived therapeutics.
- To predict future applications of combination therapies involving ascomycetes.
Main Methods:
- Literature review of studies on ascomycete secondary metabolites.
- Analysis of research demonstrating the efficacy of ascomycete compounds in various pathological states.
- Discussion of combination strategies to enhance therapeutic outcomes and mitigate side effects.
Main Results:
- Ascomycete compounds show promise in treating serious diseases.
- Combination therapy can suppress side effects and improve the therapeutic efficacy of ascomycetes.
- Co-application of ascomycete compounds can significantly enhance conventional therapies.
Conclusions:
- Combination therapy represents a viable strategy to improve the clinical application of ascomycete-derived compounds.
- This approach holds potential for enhancing existing treatments and developing novel therapeutic strategies.
- Further research into combination methodologies is warranted for future medicinal applications.
Keywords:
Filamentous ascomycetesHMGCoA reductaseNeurospora and Monascusfilamentous fungihyperlipidaemiamicrobial pigmentsoncological diseases.More Related Videos
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