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Association Between Medication Adherence and the Outcomes of Heart Failure
Sarah R Hood1, Anthony J Giazzon1, Gwen Seamon1
1College of Pharmacy, Purdue University, West Lafayette, Indiana.
Pharmacotherapy
|March 31, 2018
Summary
Improving cardiovascular medication adherence in heart failure patients significantly reduces emergency department visits, hospitalizations, and mortality. Even small increases in adherence yield substantial health benefits.
Area of Science:
- Cardiology
- Public Health
- Health Outcomes Research
Background:
- Previous studies linked cardiovascular medication adherence to reduced hospitalizations in heart failure patients.
- Limited research explored adherence impact on emergency visits, hospitalizations, and mortality in broad medical populations.
Purpose of the Study:
- To assess the association between increased cardiovascular medication adherence and health outcomes in adult heart failure patients.
- Investigated emergency department visits, hospitalizations, and mortality as key health outcomes.
Main Methods:
- Retrospective cohort study utilizing electronic health records from Indiana Network for Patient Care (2004-2009).
- Included 55,312 adult heart failure patients prescribed cardiovascular medications.
- Medication adherence measured by proportion of days covered (PDC); analyzed impact of 10% PDC increase on clinical endpoints using generalized linear models.
Main Results:
- A 10% increase in medication adherence correlated with an 11% decrease in emergency visits (RR 0.89).
- Hospital admissions decreased by 6% (RR 0.94), and total hospital stay by 1% (RR 0.99) per 10% PDC increase.
- All-cause mortality showed a 9% reduction (OR 0.91) with each 10% rise in adherence.
Conclusions:
- Higher cardiovascular medication adherence is significantly associated with improved health outcomes in heart failure patients.
- Incremental improvements in adherence correlate with reductions in healthcare utilization and mortality.
- Findings underscore the importance of medication adherence for managing heart failure and reducing adverse events.
Keywords:
electronic medical recordshealth information exchangehealth outcomesheart failuremedication adherencemortalityMore Related Videos
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