Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

3.2K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.2K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

2.2K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
2.2K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.6K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.6K
Crossing Over01:34

Crossing Over

172.3K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
172.3K
Crossing Over01:30

Crossing Over

6.6K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
6.6K
Monohybrid Crosses01:20

Monohybrid Crosses

239.8K
Overview
239.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silicon-Based Linkers for Tunable Acid-Sensitive Drug Release from Polymeric Nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery.

Macromolecules·2024
Same author

Synthesis of PEG-Polycycloether Block Copolymers: Poloxamer Mimics Containing a Rigid Helical Block.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Versatile Click Linker Enabling Native Peptide Release from Nanocarriers upon Redox Trigger.

Bioconjugate chemistry·2023
Same author

Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition.

Chemical communications (Cambridge, England)·2023
Same author

Exploring the Chemical Properties and Medicinal Applications of Tetramethylthiocycloheptyne Sulfoximine Used in Strain-Promoted Azide-Alkyne Cycloaddition Reactions.

Pharmaceuticals (Basel, Switzerland)·2023

Related Experiment Video

Updated: Feb 12, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

9.0K

Tailoring Polyethers for Post-polymerization Functionalization by Cross Metathesis.

Stephen D Morrison1, Rob M J Liskamp1, Joëlle Prunet1

  • 1WESTCHEM, School of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K.

Organic Letters
|March 31, 2018
PubMed
Summary
This summary is machine-generated.

Novel polyethers with alkene groups were functionalized using olefin cross metathesis. This method efficiently attaches small molecules, showing promise for drug delivery applications and polymer modification.

More Related Videos

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

11.2K
Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

14.8K

Related Experiment Videos

Last Updated: Feb 12, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

9.0K
Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

11.2K
Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

14.8K

Area of Science:

  • Polymer Chemistry
  • Organic Synthesis

Background:

  • Polyethers, particularly those with poly(ethylene glycol) backbones, are versatile materials.
  • Functionalizing polymers is crucial for tailoring their properties for specific applications like drug delivery.
  • Existing methods for polymer functionalization may have limitations in efficiency or scope.

Purpose of the Study:

  • To develop a novel method for functionalizing polyethers using olefin cross metathesis.
  • To demonstrate the attachment of small molecules to polyethers with pendent alkene groups.
  • To explore the potential of this method for drug delivery and broader polymer modification.

Main Methods:

  • Synthesis of novel polyethers featuring pendent alkene groups on a poly(ethylene glycol) backbone.
  • Application of olefin cross metathesis to graft small molecules onto the polyether backbone.
  • Systematic variation of alkene substitution to control reactivity and prevent self-metathesis.

Main Results:

  • Successful attachment of small molecules to polyethers via olefin cross metathesis.
  • Achieved high loading capacity, up to one compound per monomer unit.
  • Demonstrated efficient functionalization with various coupling partners, confirming proof of concept.
  • Engineered polymer structures to selectively undergo cross-metathesis over self-metathesis.

Conclusions:

  • Olefin cross metathesis is a powerful and efficient tool for functionalizing polyethers with pendent alkene groups.
  • This approach enables precise grafting of molecules for potential applications in drug delivery.
  • The methodology is adaptable for modifying a wide range of polymers containing olefin functionalities.