Related Experiment Video

Updated: Feb 12, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.1K

Myocardial fibrosis evaluated by diffusion-weighted imaging and its relationship to 3D contractile function in

Rui Wu1, Dong-Aolei An1, Ruo-Yang Shi1

  • 1Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Journal of Magnetic Resonance Imaging : JMRI
|March 31, 2018
PubMed
Abstract

Insights

Apparent diffusion coefficient (ADC) effectively detects myocardial fibrosis in hypertrophic cardiomyopathy (HCM). ADC correlates with extracellular volume and contractile function, offering a viable alternative to LGE and ECV for fibrosis assessment.

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Radiology

Background:

  • Diffusion-weighted imaging (DWI) demonstrates sensitivity to myocardial fibrosis in various cardiomyopathies.
  • Hypertrophic cardiomyopathy (HCM) is characterized by myocardial fibrosis and impaired contractile function.

Purpose of the Study:

  • To investigate the prognostic value of apparent diffusion coefficient (ADC) in detecting myocardial fibrosis within HCM.
  • To explore the relationship between ADC, myocardial fibrosis, and contractile function in HCM patients.

Main Methods:

  • A prospective study involving 45 HCM patients and 20 controls using 3.0T cardiac MRI.
  • Cardiac MR sequences included cine, T1 mapping, and DWI.
  • Assessment of ADC values for myocardial fibrosis detection and correlation with extracellular volume (ECV) and late gadolinium enhancement (LGE).

Main Results:

  • ADC values were significantly increased in patients with higher ECV and LGE, indicating greater fibrosis.
  • ADC showed a strong linear association with ECV (R²=0.65).
  • ADC values correlated significantly with impaired circumferential and longitudinal strain and strain rates.

Conclusions:

  • Apparent diffusion coefficient (ADC) is a feasible and effective tool for detecting myocardial fibrosis in HCM.
  • ADC serves as a valuable alternative to ECV and LGE for assessing fibrosis and its impact on contractile dysfunction in HCM.
Keywords:
DWIECVHCMLGEapparent diffusion coefficienttissue tracking

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.5K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
526
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
589
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
587
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
221.8K
The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
7.3K
Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.3K