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Updated: Feb 12, 2026
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A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
Published on: September 16, 2022
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Liquid Biopsies and Cancer Immunotherapy
Jonathan R Thompson1, Smitha P Menon
1From the Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226.
Cancer Journal (Sudbury, Mass.)
|March 31, 2018
Summary
Cancer immunotherapy is advancing, but identifying biomarkers remains challenging. Liquid biopsies offer a promising approach to assess a patient's immune status and predict response to cancer immunotherapy.
Area of Science:
- Oncology
- Immunology
- Biomarker Discovery
Background:
- Cancer immunotherapy has rapidly advanced, becoming a key treatment for many cancers.
- Development of tissue-based biomarkers to guide immunotherapy has lagged behind clinical progress.
- Identifying reliable biomarkers is crucial for optimizing immunotherapeutic management.
Purpose of the Study:
- To review the current literature on the application of liquid biopsies in cancer immunotherapy.
- To highlight the potential of liquid biopsies in guiding immunotherapeutic decisions.
- To discuss the advantages of liquid biopsies over traditional tissue biopsies.
Main Methods:
- Comprehensive literature search of studies investigating liquid biopsies for cancer immunotherapy.
- Analysis of current research on blood-based biomarkers and their correlation with treatment response.
- Synthesis of findings regarding the utility of liquid biopsies in clinical practice.
Main Results:
- Liquid biopsies provide a less invasive method to evaluate the tumor immune microenvironment.
- Emerging evidence suggests liquid biopsies can predict patient response to immunotherapy.
- Biomarkers identified through liquid biopsies may help personalize cancer treatment strategies.
Conclusions:
- Liquid biopsies represent a significant advancement in biomarker development for cancer immunotherapy.
- Their potential to guide treatment decisions and improve patient outcomes is substantial.
- Further research is warranted to fully establish the role of liquid biopsies in clinical oncology.
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