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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Acupuncture in a Rat Model of Asthma
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Phenotypes/endotypes-driven treatment in asthma.

Fulvio Braido1, Angelica Tiotiu2, Krzysztof Kowal3

  • 1Respiratory and Allergy Department, University of Genoa, Ospedale Policlinico San Martino, Genoa, Italy.

Current Opinion in Allergy and Clinical Immunology
|March 31, 2018
PubMed
Summary
This summary is machine-generated.

Personalized asthma treatment advances with phenotype and endotype identification. New targeted therapies, including monoclonal antibodies, are improving outcomes for various asthma types.

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Area of Science:

  • Pulmonology and Immunology
  • Translational Medicine
  • Pharmacology

Background:

  • Asthma treatment is shifting towards personalized medicine.
  • Identifying distinct asthma phenotypes and their underlying mechanisms (endotypes) is crucial for developing targeted therapies.
  • Advances in big data analysis, biomarker research, and monoclonal antibody development are driving rapid progress.

Purpose of the Study:

  • To review recent advances in understanding asthma phenotypes and endotypes.
  • To highlight the development of targeted therapies based on these classifications.
  • To provide an overview of the evolving landscape of asthma management.

Main Methods:

  • Literature review of recent studies on asthma phenotypes and endotypes.
  • Analysis of biomarker research and clinical trial data.
  • Examination of the development and application of targeted biologic therapies.

Main Results:

  • While phenotype identification has faced challenges, significant progress has been made in understanding asthma endotypes (e.g., Th2-low and Th2-high).
  • This has led to the development of effective targeted treatments such as anti-IgE, anti-IL5, and anti-IL5R therapies.
  • Biomarker discovery is enabling more precise treatment selection for specific asthma patterns.

Conclusions:

  • The classification of asthma into distinct endotypes represents a paradigm shift in asthma management.
  • Targeted therapies based on endotype identification are revolutionizing asthma care.
  • Ongoing research promises further advancements in personalized asthma treatment strategies.