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Updated: Feb 12, 2026

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Corneal Cross-Linking for Pediatric Keratcoconus Review.

Claudia Perez-Straziota1,2, Ronald N Gaster2,3, Yaron S Rabinowitz2,4,5

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Pediatric cross-linking halts keratoconus progression, offering cost-effective early treatment. However, long-term data and regression rates for pediatric keratoconus require further investigation.

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Area of Science:

  • Ophthalmology
  • Pediatric eye care

Background:

  • Keratoconus is a progressive eye condition affecting the cornea.
  • Pediatric keratoconus management requires specific considerations due to growth and development.

Purpose of the Study:

  • To conduct a comprehensive literature review on corneal cross-linking (CXL) in pediatric patients.
  • To evaluate the efficacy and safety of CXL for pediatric keratoconus.

Main Methods:

  • Systematic review of English-language publications.
  • Literature search conducted using the PubMed database.

Main Results:

  • A total of 210 publications were initially identified.
  • 115 publications were deemed relevant for inclusion in the review.
  • Existing studies are limited by small sample sizes and short follow-up durations.

Conclusions:

  • Corneal cross-linking effectively halts keratoconus progression in pediatric patients.
  • Early CXL treatment appears more cost-effective than later corneal transplantation.
  • Long-term outcomes and potential regression rates of CXL in children warrant further research.