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Updated: Feb 12, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Corneal Cross-Linking for Pediatric Keratcoconus Review
Claudia Perez-Straziota1,2, Ronald N Gaster2,3, Yaron S Rabinowitz2,4,5
1Department of Ophthalmology, University of Southern California, Los Angeles, CA.
Purpose:
To comprehensively review the available published literature for cross-linking in the pediatric population.
Methods:
Review of the literature published in English in PubMed.
Results:
Two hundred ten publications were considered. One hundred fifteen were considered relevant to this review.
Conclusions:
Studies of cross-linking in pediatric patients are sparse, with relatively short follow-up times, and mostly on small groups of patients. Treatment with cross-linking halts progression of keratoconus in the pediatric population, and early treatment seems to be cost-effective compared with later penetrating keratoplasty. Long-term effects and regression rates remain unclear, and further studies are needed in this population.
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