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Design and Rationale of the Cognitive Intervention to Improve Memory in Heart Failure Patients Study

Susan J Pressler1, Bruno Giordani, Marita Titler

  • 1Susan J. Pressler, PhD, RN Director, Center for Enhancing Quality of Life in Chronic Illness, and Professor and Sally Reahard Chair, Indiana University School of Nursing, Indianapolis. Bruno Giordani, PhD Professor, Neuropsychology Program, Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor. Marita Titler, PhD, RN Professor, Rhetaugh Dumas Endowed Chair, and Department Chair, Systems, Populations and Leadership, University of Michigan School of Nursing, Ann Arbor. Irmina Gradus-Pizlo, MD Clinical Professor, Division of Cardiology, University of California, Irvine. Dean Smith, PhD Professor and Dean, School of Public Health, Louisiana State University Health Sciences Center, New Orleans. Susan G. Dorsey, PhD, RN Professor and Department Chair, Department of Pain and Transitional Symptom Science, University of Maryland School of Nursing, Baltimore. Sujuan Gao, PhD Professor, Department of Biostatistics, Indiana University School of Medicine, Indianapolis. Miyeon Jung, PhD, RN Assistant Professor, Indiana University School of Nursing, Indianapolis.

The Journal of Cardiovascular Nursing
|March 31, 2018
PubMed

Insights

This study investigated BrainHQ, a computerized cognitive training program, for heart failure patients experiencing memory loss. Results will inform new therapeutic approaches for this common comorbidity.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Memory loss is prevalent in heart failure patients, predicting mortality.
  • Few effective interventions exist for cognitive impairment in heart failure.
  • This study addresses a critical unmet need in heart failure management.

Purpose of the Study:

  • To evaluate the efficacy of computerized cognitive training (BrainHQ) for memory and neurotrophic factor improvement in heart failure patients.
  • To assess the cost-effectiveness of the BrainHQ intervention.
  • To explore the influence of depressive symptoms and genetics on BrainHQ's effectiveness.

Main Methods:

  • A 3-arm randomized controlled trial involving 264 heart failure patients.
  • Participants assigned to BrainHQ, crossword puzzles (active control), or usual care.
  • Data collected at baseline, 10 weeks, 4 months, and 8 months, with intent-to-treat analysis.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • The research will yield novel insights into BrainHQ's potential to enhance memory and brain-derived neurotrophic factor in heart failure.
  • If effective, BrainHQ offers a disseminable therapeutic strategy for a significant heart failure comorbidity.
Abstract

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