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Left ventricular mass independently associates with masked hypertension in young healthy adults: the African-PREDICT

Nare P Sekoba1, Ruan Kruger1,2, Pieter Labuschagne1

  • 1Hypertension in Africa Research Team, Faculty of Health Sciences.

Journal of Hypertension
|March 31, 2018
PubMed

Insights

Masked hypertension in young adults is linked to increased left ventricular mass index, indicating a higher risk for cardiovascular disease. Early detection is crucial for this apparently healthy population.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Preventive Medicine

Background:

  • Masked hypertension, characterized by normal blood pressure in clinical settings but elevated during ambulatory monitoring, is increasingly recognized in young adults.
  • The presence of subclinical organ damage, specifically cardiac changes, in young individuals with masked hypertension remains largely unexplored.

Purpose of the Study:

  • To investigate the association between masked hypertension and left ventricular structure and function in young, seemingly healthy adults.
  • To determine if early signs of cardiovascular disease are present in young individuals with masked hypertension.

Main Methods:

  • A cross-sectional study involving 774 healthy men and women aged 20-30 years.
  • Ambulatory blood pressure monitoring and echocardiography were performed to assess blood pressure and left ventricular parameters.
  • Statistical analyses, including multivariable-adjusted logistic and linear regression, were employed to identify associations.

Main Results:

  • Masked hypertension was identified in 16.4% of the study participants.
  • Individuals with masked hypertension showed significantly higher odds of increased left ventricular mass index compared to normotensive individuals (OR 1.67, P=0.031).
  • Left ventricular mass index was positively and independently associated with masked hypertension (adjusted R²=0.193, P=0.046), while no independent link was found with left ventricular function.

Conclusions:

  • Young adults with masked hypertension exhibit subclinical cardiac changes, specifically increased left ventricular mass index.
  • These findings underscore the importance of early detection and management of masked hypertension in young individuals to mitigate future cardiovascular disease risk.
Abstract

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